Short or Poor Sleep Can Lead to More Eating and Risk of Diabetes

Studies continue to show that sleep curtailment or decreased sleep quality can disturb neuroendocrine control of appetite, leading to overeating, and can decrease insulin or increase insulin resistance, both steps on the road to Type 2 diabetes.

On April 22, at the Experimental Biology 2009 meeting in New Orleans, a panel of leading sleep researchers describes recent and new studies in this fast growing field. The session is part of the scientific program of the American Association of Anatomists (AAA).

Short sleep, poor sleep: novel risk factors for obesity and for type 2 diabetes.

Dr. Eve Van Cauter, University of Chicago, is a specialist in the effect of circadian rhythms on the endocrine system and has conducted several studies in which short-term sleep restriction damaged the body’s ability to regulate eating by lowering levels of leptin, the hormone that tells the body when it has had enough. In the AAA symposium, Dr. Van Cauter describes other recently published studies from her group, one showing that only three days sleep disruption is sufficient to increase insulin resistance in humans (thus causing the body to need higher levels of insulin) and a large epidemiological study showing that short sleep over a five year period causes an increase in systolic blood pressure.

Energy metabolism during chronic sleep deprivation: sleep less, eat more, don’t gain weight, yet show signs of progression toward diabetes.

Panel member Dr. Michael Koban, Morgan State University, reports a new study in which sleep restriction in rats led to glucose intolerance, a prediabetic state in which the blood glucose remains higher than normal after glucose challenge. Significantly, this is the first rodent study of sleep deprivation in which there was no association between glucose dysregulation and weight gain.

The researchers believe that extending sleep restriction will produce more pronounced glucose intolerance in which glucose levels do not return to normal levels for a longer period, thus providing more evidence that not sleeping enough could lead to diabetes in humans. The researchers also are looking for mechanisms to explain the change in metabolism related to sleep deprivation and the dissociation between weight gain and glucose dysregulation and insulin resistance.

Stress-related behaviors and hormone changes after prolonged sleep deprivation – and environmental factors that appear to modify them

Dr. Deborah Suchecki, Universidade Federal de Sao Paulo, describes how prolonged sleep deprivation activates the neuroendocrine stress response, as measured by increased blood levels of the stress-related hormones adrenaline, adrenocorticotropic hormone (ACTH), and corticosterone. Earlier studies have shown that sleep restriction in animals can gradually change brain and neuroendocrine systems in ways similar to those seen in stress-related disorders such as depression, while epidemiological studies suggest that sleep restriction may be an important risk factor for cardiovascular and other diseases linked to stress.

CNS changes after chronic sleep deprivation have role in both food intake and metabolism.

Dr. Gloria Hoffman, also of Morgan State University, presents studies that explain the role of the central nervous system pathways in stimulating feeding and causing metabolic changes associated with progression to diabetes. Specifically, increased production of the neurotransmitter neuropeptide Y and decreased production of proopiomelanocortiini products in the hypothalamus explain the hyperphagic response.

Although the CNS’s role in regulating metabolic rate is not well understood, she believes that histamine might be involved. Histamine neurons not only affect the maintenance of wakefulness but also are regulators of peripheral metabolism. In sleep deprived rats, elevations in the glucose to insulin ratio were positively correlated with an increase in histamine expression that raises the possibility that a dysregulation of histamine function during impaired sleep might serve to trigger metabolic and other changes leading to diabetes.

The scientists agree that as sleep curtailment becomes more common in industrialized countries it becomes increasingly important to understand how limited or poor quality sleep produces changes that can lead to obesity and diabetes, both epidemic in the developed world. More and more scientists are jumping on board with these lines of investigation, says Dr. Hoffman, and there is an increased demand for information on the part of health professionals and members of the general public, many of whom consider themselves sleep deprived.

Kids Like Fruits and Veggies When Given a Chance

The good nutrition news is that children in poor, rural parts of the Lower Mississippi Delta are a lot more willing to try fresh fruits and vegetables than generally believed, even by their parents or the kids themselves. The bad news is that such foods are often in short supply in an area where gas stations and convenience stores are the closest places to buy food and where growing family gardens has given way to long work commutes by parents – and that the situation is growing worse with a worsening economy.

Two presentations drawing from a multi-year nutrition research program in Delta summer camps and schools were presented on April 19 at the Experimental Biology 2009 meeting in New Orleans as part of the scientific program of the American Society for Nutrition. The ongoing research program is being conducted under the direction of research nutritionist Dr. Beverly McCabe-Sellers, US Department of Agriculture/Agricultural Research Service, Little Rock, Arkansas, and is part of the Delta Obesity Prevention Research Unit (OPRU) headed by Executive Director Dr. Margaret Bogle.

The research arm of the Delta OPRU works with local communities to understand obstacles to better nutrition in the Lower Delta (including rural parts of Arkansas, Louisiana and Mississippi), which leads the nation in the rising prevalence of obesity in both adults and children.

The challenge to having more fruits and vegetables in the diets of youngsters is not their unwillingness, she says, nor is it necessarily the admittedly low income in the area. Potato chips are not inexpensive, but the children often had small bags of them for every meal. The largest challenge, she believes from her experience, is the difficulty in obtaining quality fresh produce at a reasonable cost in these rural areas far away from distribution centers.

Epidermal Growth Factor Receptor Found for Pancreatic Cancers

Finally some promising news about pancreatic cancer, one of the most fatal cancers, due to the difficulties of early detection and the lack of effective therapies: Johns Hopkins University pathologist Akhilesh Pandey has identified an epidermal growth factor receptor aberrantly active in approximately a third of the 250 human pancreatic cancers studied.

In a presentation April 18, at Experimental Biology 2009 in New Orleans, Dr. Pandey explained why this finding and related work in his Hopkins laboratory is promising in terms of both a new treatment for a large subset of pancreatic cancers and a potential blood or urine screening tool that might eventually do for pancreatic cancer detection what biomarkers like prostate-specific antigen levels have done for prostate cancer. His presentation was part of the scientific program of the American Society for Investigative Pathology.

Personalized treatment. Phosophorylated epidermal growth factor receptor (pEGFR), the receptor identified by Dr. Pandey, is closely related to HER-2, a growth factor receptor found and used as a drug target in a subset of breast cancers. After he found and profiled the pEGFR activated in the pancreatic cancers, Dr. Pandey realized the same receptor had been found by other researchers to be activated in a subset of lung cancers. And, most promising, an EGFR inhibitor named erlotinib already has been through the long and complex Food and Drug Administration approval process and is in use for treatment of these specific lung cancers.

But would the drug work in pancreatic cancers? Dr. Pandey’s group moved from studies of human cell lines to studies in mice in which human pancreatic tumor cells with activated EGFT had been placed. The tumors began growing. But when treated with erlotinib, they began to shrink. Other tumors without activated pECFR showed no response.

The promise – and the challenge – of using pEGFR is that of personalized medicine, says Dr. Pandey. Obviously a growth factor receptor that is activated only in a subset of all pancreatic cancers cannot be a one-size-fits-all target for treatment. Earlier studies in other laboratories and clinical trials already had tried EGF inhibitors as a treatment for pancreatic cancer and concluded that they did not work. When Dr. Pandey’s collaborators allowed them to re-examine their samples, they found that the only case in 12 cases that had responded to the EGF inhibitor was the only case with an activated EGF receptor. Dr. Pandey would like to see other researchers go back and re-analyze their data, separating patients with and without the activated receptor, and then determining the success rate. He believes it would tell a different, more hopeful story.

Screening for pancreatic cancer. Dr. Pandey’s other goal in his research is to use mass spectrometry to find additional markers of pancreatic cancer in the tumors themselves but also in blood and urine, which would avoid the problems of invasive biopsies. As a first step, his team has gone through the scientific literature to create a compendium of several hundred proteins and genes reported to be overexpressed in pancreatic cancers, making them excellent candidates for further study. The compendium already is being used by a consortium of investigators who are developing antibodies against the 60 most promising targets.

Brain Waves Synchronicity

Scientific American continues to produce the best coverage of science and the mind. The story on musicians and how they sync efforts is interesting. Thank you to Movietome Beta for the image of the album by The Police called Synchronicity.

I like the description on Wikipedia on synchronicity: Synchronicity is the experience of two or more events which are causally unrelated occurring together in a supposedly meaningful manner. In order to count as synchronicity, the events should be unlikely to occur together by chance. The concept does not question, or compete with, the notion of causality. Instead, it maintains that just as events may be grouped by cause, they may also be grouped by their meaning. Since meaning is a complex mental construction, subject to conscious and subconscious influence, not every correlation in the grouping of events by meaning needs to have an explanation in terms of cause and effect.

Jordan Lite's 60-Second Science blog, says, "Ever wonder how musicians manage to play in unison? Credit their brain waves: they synchronize before and while musicians play a composition, according to new research. German scientists report in BMC Neuroscience that they measured the brain waves of eight pairs of guitarists using electroencephalography (EEG) while they played a modern jazz piece called Fusion #1 (by Alexander Buck). The researchers found that the guitarists' brain waves were aligned most during three pivotal times: when they were syncing up with a metronome, when they began playing the piece and at points during the composition that demanded the most synchrony."

Intellectual Property Rights - Legal Stays Busy

Since I work in the medical discovery world I like to keep up with the business side of innovation, and this one hits home on a big issue of intellectual property rights for the new century.

Newsweek's Michael Heller covers the troubles in "Innovation Gridlock- Today's inventors need to put together many bits of intellectual property. Too bad they are all patented."

[Image from Vaugn Merlyn]

Newsweek writes, the first decade of the 21st Century has seen startling advances in biology. Scientists have cracked the genomes of humans and many plants, animals and microbes. They've uncovered new cellular processes affecting inheritance of diseases. Likewise, investment in biotech research and development has been steadily increasing. So what happened to all the lifesaving cures that were supposed to come our way as a result?

Read this story.

No Doubt Facinating - the Life of a Savant

Scientific American is providing an interesting read this week with an interview with Daniel Tammet, a person SA says is an autistic savant. Read more. Also, while looking I came across this doctor who studies savants: Darold Treffert. He discusses Tammet here and many savants here. Photo credit.

Evidently the world has been aware of Tammet since 2004 when he one the Pi contest -Tammet's web site.

Good quote: "My brain has developed a little differently from most other people’s. Aside from my high-functioning autism, I also suffered from epileptic seizures as a young child. In my book, I propose a link between my brain’s functioning and my creative abilities based on the property of ‘hyper-connectivity’. "

Daniel Tammet is the author of two books, Born on a Blue Day and Embracing the Wide Sky, which comes out this month. He’s also a linguist and holds the European record for reciting the first 22,514 decimal points of the mathematical constant Pi. Mind Matters editor Jonah Lehrer chats with Tammet about how his memory works, why the IQ test is overrated, and a possible explanation for extraordinary feats of creativity.

LEHRER: Your recent memoir, Born on a Blue Day, documented your life as an autistic savant. You describe, for example, how you are able to quickly learn new languages, and remember scenes from years earlier in cinematic detail. Are you ever surprised by your own abilities?

TAMMET: I have always thought of abstract information—numbers for example—in visual, dynamic form. Numbers assume complex, multi-dimensional shapes in my head that I manipulate to form the solution to sums, or compare when determining whether they are prime or not. For languages, I do something similar in terms of thinking of words as belonging to clusters of meaning so that each piece of vocabulary makes sense according to its place in my mental architecture for that language. In this way I can easily discern relationships between words, which helps me to remember them. In my mind, numbers and words are far more than squiggles of ink on a page. They have form, color, texture and so on. They come alive to me, which is why as a young child I thought of them as my “friends.” I think this is why my memory is very deep, because the information is not static. I say in my book that I do not crunch numbers (like a computer). Rather, I dance with them. None of this is particularly surprising for me. I have always thought in this way so it seems entirely natural. What I do find surprising is that other people do not think in the same way. I find it hard to imagine a world where numbers and words are not how I experience them!

Finding Science Instruction on the Internet

You knew it was just a matter of time until the Internet provided intellectual content at a level an industrious amatuer scientist could fiddle with. In Newsweek, an AP reporter Marcus Wohlsen writes about this endeavor.

The prospects could have major implications for NIH, major pharma, universities, and more. How will the money flow and what will the standards be in years to come?

Read more at Newsweek: "The Apple computer was invented in a garage. Same with the Google search engine. Now, tinkerers are working at home with the basic building blocks of life itself.
Using homemade lab equipment and the wealth of scientific knowledge available online, these hobbyists are trying to create new life forms through genetic engineering — a field long dominated by Ph.D.s toiling in university and corporate laboratories."

Thanks to Ingenuity Works for the image.

Hawking Continues his Universe Quest

If anyone is looking for a hero, you can start with Stephen Hawking. News today says Stephen Hawking will become the first distinguished research chair at Canada’s leading scientific trust, the Perimeter Institute for Theoretical Physics in Waterloo, Ontario. Hawking will make regular visits to the institute, which focuses on quantum theory and gravity, beginning next summer. He will continue to hold his position as a professor of mathematics at Cambridge University.

Besides the fact that Hawking is brilliant, he is an amazing person for his perserverence against his disability from ALS. He says, "I am quite often asked: How do you feel about having ALS? The answer is, not a lot. I try to lead as normal a life as possible, and not think about my condition, or regret the things it prevents me from doing, which are not that many."

His web site says, "Hawking has worked on the basic laws which govern the universe. With Roger Penrose he showed that Einstein's General Theory of Relativity implied space and time would have a beginning in the Big Bang and an end in black holes. These results indicated it was necessary to unify General Relativity with Quantum Theory, the other great scientific development of the first half of the 20th Century. One consequence of such a unification that he discovered was that black holes should not be completely black, but should emit radiation and eventually evaporate and disappear. Another conjecture is that the universe has no edge or boundary in imaginary time. This would imply that the way the universe began was completely determined by the laws of science.

"His many publications include The Large Scale Structure of Spacetime with G F R Ellis, General Relativity: An Einstein Centenary Survey, with W Israel, and 300 Years of Gravity, with W Israel. Stephen Hawking has three popular books published; and his best seller A Brief History of Time."

How Does an Iconoclast Think?

I like to cover stories about innovation on my personal blog, The Sky Badge Project, but I think this has interesting scientific merit so I am posting two places.

From an Emory University press release we learn about a new book: Iconoclast: A Neuroscientist Reveals How to Think Differently (Harvard Business Press, 2008) - Gregory Berns, MD, PhD, shows us how the world's most successful innovators think and what we can learn from them.

Berns is distinguished chair of neuroeconomics, professor of economics at Emory University, and professor of psychiatry and behavioral sciences, Emory University School of Medicine. He focuses his research on human motivation and decision-making through a blend of neuroscience, economics and psychology.

"Iconoclasts are individuals who do things that others say can't be done," explains Berns. "An iconoclast defies the rules, but given the opportunity, can be an asset to any organization because of the skill to be creative and innovative despite adversity."

The book examines the stories of famous and not-so-famous iconoclasts to learn something about creative decision-making, innovation and creativity and the ability to control fear, and to look at the neuroscience behind those processes. Berns profiles people such as Walt Disney, the iconoclast of animation; Natalie Maines, an accidental iconoclast; and Martin Luther King, who conquered fear.

Berns says that many successful iconoclasts are made not born. For various reasons, they simply see things differently than other people do.

"Certainly there are people who are born this way, but what I have been able to learn about these individuals is that most successful iconoclasts are people who are skilled at handling failure and particularly at handling fear - fear of failure, fear of the unknown," says Berns.
He also discovered a trait that ultimately distinguishes the people who are really successful is social intelligence.

"A person can have the greatest idea in the world - completely different and novel - but if that person can't convince enough other people, it doesn't matter," says Berns.

Pluses for HRT in Postmenopausal Women

American women can stay confused about hormone replacement for postmenopausal health with all of the reports talking about its benefits, but then warning of its harm.

Here is the latest news from a Eurekalert press release reporting on a study in the British Medical Journal. The photo comes from JAMD.

One of the world's longest and largest trials of hormone replacement therapy (HRT) has found that post-menopausal women on HRT gain significant improvements in quality of life.

The results of the latest study by the WISDOM research team (Women's International Study of long Duration Oestrogen after Menopause) are published today on the British Medical Journal website http://www.bmj.com/.

The study involved 2130 post-menopausal women in the UK, Australia and New Zealand, and assessed the impact of combined oestrogen and progestogen hormone therapy on the women's quality of life. The average age of women in this study was 13 years after menopause and most participants did not have menopausal symptoms.

"Our results show that hot flushes, night sweats, sleeplessness and joint pains were less common in women on HRT in this age group. Sexuality was also improved," says Professor Alastair MacLennan, leader of the Australian arm of WISDOM and head of Obstetrics & Gynaecology at the University of Adelaide, Australia.

"Overall, quality of life measures improved. Even when women did not have hot flushes and were well past menopause, there was a small but measurable improvement in quality of life and a noted improvement in sleep, sexuality and joint pains. HRT users also had more breast tenderness and discharge compared to those on a placebo," he says.

Dr Beverley Lawton, Head of WISDOM New Zealand, says: "These new data should be added to the risk/benefit equation for HRT. The quality of life benefits of HRT may be greater in women with more severe symptoms near menopause. New research suggests that HRT taken from near menopause avoids the cardiovascular risks seen when HRT is initiated many years after menopause."

Professor MacLennan says studies such as those conducted by WISDOM "enable the risks of HRT to be reduced and its benefits maximized when the treatment is individualized to each woman".

"Early start-up side effects can usually be alleviated by adjusting the treatment," he says. "For most women with significant menopause symptoms the benefits of HRT outweigh the risks. The latest analyses of the main long-term randomized control trial of HRT (The Women's Health Initiative) show that breast cancer is not increased by estrogen-only HRT and is only increased in women using combined oestrogen and progestogen HRT after seven years of use. This increased risk is less than 0.1% per year of use.

"If a woman feels that HRT is needed for quality of life, then doctors can find the safest regimen for her. She can try going off HRT every 4-5 years, and can then make an informed choice about whether she takes and continues HRT."

Gamma-Ray Bursts Give Awesome Afterglow

I have been enjoying the Scientific American web site today, and always take a look at the physics section - written to help a non-physicist get it! I wanted to put the spectacular image in my blog, with credit, but I am not sure if this is allowed. So visit the story to see it! Instead I have used an image I found on Google and credit goes to scubagrl.

Writer JR Minkel says, "A new study casts doubt on a long-standing belief about the power behind gamma-ray bursts, the most energetic explosions in the universe. Researchers have found that short gamma-ray bursts—those that last a couple of seconds or less—have brighter afterglows than the simple, reigning model of afterglow emission predicts. Gamma-ray bursts (GRBs) are believed to occur when a star that has collapsed into a black hole or a neutron star whips a disk of gas and dust into a pair of powerful jets moving at nearly light speed. Like a lighthouse in fog, these so-called relativistic jets should cause whatever gas and dust that enshrouds the GRB source to glow brightly for hours after the burst's initial flash of energy."

North Pole's Changes Bring Grim News

The headline in TIME really caught my eye because it was a big surprise even with all the news about ice at the earth's poles: An Ice-Free North Pole?

TIME writer Seth Borenstein says a scientist he talked with notes, "There's a 50-50 chance that the North Pole will be ice-free this summer, which would be a first in recorded history..... Preliminary February and March data from a NASA satellite shows that the circle of ice surrounding the North Pole is "considerably thinner" than scientists have seen during the five years the satellite has been taking pictures.... For the last couple of decades, there has been a steady melt of Arctic sea ice — which covers only the ocean and which thins during summer and refreezes in winter. In recent years, it has gradually become thinner because more of it has been melting as the Earth's temperature rises."

Of course, scientists are looking for solutions, but how could it possibly be in time to reverse these dramatic and fast-moving changes?

Fixing the Brain with new Technologies

Now technology has moved well into the neuro business of health care. With money to be made on new advances in technology for problems of the brain and its workings, we will see more companies moving forward scientists' discoveries.

Conde Nast Portfolio has a nice summary - a lengthy piece describing the growth: "It seems far out even for the neurotechnology industry, a rapidly growing cluster of companies—small upstarts as well as pharmaceutical giants—that want to alter your gray matter and make billions of dollars in the process. These firms are trying to adapt groundbreaking research into the basic workings of the brain to new drugs for ailments ranging from insomnia to multiple sclerosis. Some companies are trying to regrow portions of the brain using stem cells. Others have developed implants to insert into a person’s head to control seizures and restore hearing."

Innovation in Many Places

On the hunt for innovation, I bumped into this article from the Edmonton Journal. I am excerpting a lot of it, but you can read more on the web site. I like the quote below by the Xerox president of its Innovation Group.

Emerging new technology products were shown this week at PARC of Xerox Corp. The centre has long been part of a Xerox corporate strategy of investing in long-range research. PARC incubates ideas that have the potential to become marketable products because they are dreamed up with partners from business, government and schools.

"We strongly believe whatever we think of will work," said Sophie Vandebroek, Xerox chief technology officer and president of Xerox Innovation Group.

Rare cell detector
Tucked away in the farthest PARC basement corner, biomedical research manager Dr. Richard Bruce places a microscope-like slide containing millions of white blood cells on a special scanner. The device shines a modified print laser blue light on cells that have been stained with fluorescent material. An attached scanner reads reflected light. Normal cells are a uniform solid colour. But abnormal cells reflect a different colour. The new, highly sensitive instruments can find a single rogue cancerous cell in a sample of more than 10 million cells in less than 30 minutes. The system potentially enables accelerated diagnosis and treatment of quickly spreading cancer cells. The detector is scheduled for tests at Stanford Hospital later this year.

The detector also has the potential to replace an invasive and sometimes hazardous method of testing body fluids in babies before birth known as amniocenteses. The new technology instead zeros in on embryo blood cells floating around in a mother's blood sample.

Erasable paper
Dr. Paul Smith, laboratory manager for the Xerox Research Centre in Missassauga, Ont., couldn't contain his excitement over results of PARC work that started as a Canadian project. The copying technology wizards are developing printable paper that wipes itself clean in 24 hours, or sooner if you decide to reuse it. The yellow base paper - coloured to distinguish itself from traditional, permanently printed paper - does not use ink. Smith said the specially coated paper produces dark tones when exposed to a certain kind of light the laser printer produces.

The effect fades away in 24 hours. The new variety of copier paper can be used up to 100 times, saving money and reducing office and household trash. Smith said a special hand-writing stylus is also in the works.

Solar concentrator
Developed with partner SolFocus, Inc., this is an array of clear plastic paraboliclike mirrors that miniaturizes solar panels. An array of the new type that is only the size of a large button can concentrate sunlight 500 times. The invention means potentially drastic reductions in the size of conventional solar panels and in the use of expensive silicon. It integrates the optical, thermal, and electrical aspects of solar panels to a single, flat, solid piece of glass. Scott Elrod, manager of the Clean Technology Program, expects this technology to cut the costs of traditional methods of harnessing sun energy in half.

Water purifier
Xerox's experience in handling powder-like toner material for its printers has led to a simple but effective method of separating solid particles from water. Particle-laden water is flushed through a spiral tube. As the material flows, centrifugal force separates solids from water. Elrod said water treatment plants can use this technology to remove solids from water and save time and space.

Getting Credit Where Credit Is Due

I am excerpting briefly from author Michael Domjan in the April 2008 Observer on the Psychological Science web site, but the article about credit for work in science in the age of interdisciplinary work is very interesting!

It says, "These days, the term “credit crisis” invokes thoughts of Wall Street and financial debt. But in the scientific enterprise, structural changes are affecting core issues of intellectual credit and indebtedness as well as taking responsibility when problems arise. Interdisciplinary and transdisciplinary have almost become buzz words, but they signify much more than just fashionable labels. Their commonplace use reflects the fact that deep understanding of a problem often requires the coordinated efforts of a range of scientists who are expert at different levels of analysis and employ different specialized techniques. When teams apply for grants and research awards, it may be difficult to name the principal investigator (PI). Beginning in February 2007, the National Institutes of Health added a multiple principal investigator option for grant and award applications." Vist the web site to read more!

Tea Catechins Linked to Reduction of Cancers

Increased consumption of teas rich in catechins is associated with reduced risk of stomach, colon, and other gastrointestinal cancers. However, the effects of digestion on the anticancer activity of tea catechins have largely been ignored. A study by nutrition researchers at The Ohio State University and Purdue University found that the digestive process could both alter the structure of the tea catechins and their anticancer activity.

Results were presented April 7 at Experimental Biology 2008 in San Diego.

Using a model simulating gastric and small-intestinal digestion, the researchers treated gastric cancer cells and colon cancer cell lines with digested and undigested (parent) extracts of green, tea, black tea, and a combination of the most active tea catechins (EGCG/EGC).
In colon cells, digestion of both the green tea extracts and the catechin combination significantly reduced anticancer activity compared to undigested parent extracts. Black tea, on the other hand, showed the same anticancer activity for both parent and digested extracts.

Digestion and the type of tea made a difference in terms of anticancer activity. In addition, the anticancer activity of the tea extracts differed between gastric and colon cancer cell lines. In gastric cancer cells, the undigested extracts were 50 percent less effective than in colon cancer cells.

What does the new study show us?

First, says Dr. Bomser, it points out that better understanding the impact of digestion on tea could lead to changes in how we formulate products in order to protect and enhance their anticancer activity. It also could change how we prepare tea now. In a study from Dr. Ferruzzi’s laboratory published last November, for example, he found that adding citrus (such as lemon juice) or ascorbic acid to green tea protected the catechins from digestive degradation. Lemon juice caused 80 percent of tea’s catechins to remain available for the body to absorb.

Second, say the researchers, some of the digestive changes may impact anti-cancer activities. Work in Dr. Ferruzzi’s laboratory has shown that digestion can alter the structure of polyphenols, degrading and destroying some while forming others. His laboratory is currently identifying these new compounds and testing their own anticancer activity.

Third, the findings of digestive impact on tea catechins are likely also true for other bioactive compounds in foods. Dr. Bomser points out that the active compound in broccoli, for example, is not released until chewing and the digestive process begins. How do we formulate food to prevent degradation and perhaps enhance anti-cancer activity?

And fourth, say the researchers, the epidemiological findings of protective impact of teas rich in the unstable, easily degraded catechins may indicate that other compounds in tea are responsible, in part, for this anticancer activity. Further research is necessary to identify these compounds and to understand the impact of digestion on their anticancer activity.

Experimental Biology 2008 - Freshman 15 Update

The “freshman 15” - the rapid weight gain believed to afflict many new college students when they begin school - appears to be a bit of an urban legend: a cautionary tale often told but not well substantiated.

Now a study of 36 freshmen reports an average gain of only 1.9 pounds during the first semester, with women gaining slightly more than men, and an average gain of only 4.8 pounds for the entire freshman year (with males gaining an average of 5.4 pounds and women gaining an average of 3.2 pounds).

Some students lost weight. But even when only those who gained were considered, the average weight gain was 5.8 pounds, a long way from the often-popularized 15.

Dr. Sareen Gropper presented the study at the Experimental Biology 2008 meeting in San Diego.

The 36 freshman (26 females and 10 males) were weighed and their body composition and shape measured when they began college and then again at the end of the fall semester and the end of the spring semester. The urban legend is correct in the sense that a majority of freshmen in the study (71.4 percent) did gain weight, notes Dr. Gropper, but only 21 percent gained five pounds or more.

The largest gainers in the fall semester were a woman who gained nine pounds and a male who gained 10 pounds. For the academic year, the largest weight gains observed were 13 pounds for one male and 12 pounds for one female. No one gained the freshman 15. Dr. Gropper and colleagues have begun a larger study of 240 students who entered Auburn in the fall semester of 2007.

She and her colleagues are following the 240 students throughout their freshman and beginning of their sophomore years, with questionnaires that examine factors that might contribute to the gain, however small, that the majority of college freshman appear to experience. The researchers also are collecting data on weight changes throughout the year, including five, 10, even 15+ pound losses within the first year of school.

Unique to this study is a 3-D whole body scanner to collect information on body size and shape. This technology quickly captures exact body measurements, which can be visually displayed in cross sections of body areas like the bust, waist and hips to show where changes occur in measurements over time. Understanding where weight is deposited on the body helps assess the potential risk of diseases such as heart disease and metabolic syndrome.

Experimental Biology 2008: Ibuprofen Helps Build Muscle Mass

Scientists say taking daily recommended dosages of ibuprofen and acetaminophen caused a substantially greater increase over placebo in the amount of quadriceps muscle mass and muscle strength gained during three months of regular weight lifting.

Dr. Todd Trappe reported study results at Experimental Biology 2008 in San Diego on April 6.

Participants took three months of weight training, 15-20 minute sessions in a Human Performance Laboratory three times per week. The researchers knew from their own and other studies that training at this intensity and for this time period would significantly increase muscle mass and strength. They expected the placebo group to show such increases, as its members did, but they were surprised to find that the groups using either ibuprofen or acetaminophen did even better.

Over three months, says Dr. Trappe, the chronic consumption of ibuprofen or acetaminophen during resistance training appears to have induced intramuscular changes that enhance the metabolic response to resistance exercise, allowing the body to add substantially more new protein to muscle. Read more.

Diseases in our New World Order

I find this facinating, even though risk to others is low. The NYT says on Long Island Nassau County officials issued a health advisory on Saturday to anyone who had recently eaten at an Italian chain restaurant in Hicksville, after a worker there was found to have typhoid fever.

County health officials said a New York City man who is a food handler at Mama Sbarro’s, at 265 North Broadway, contracted typhoid fever, a bacterial infection that can be life-threatening if not treated.

New York City health officials informed the Nassau County Department of Health about the man’s infection on Friday night, a spokeswoman for the county health agency said.

The spokeswoman, Cynthia Brown, said that based on interviews with the man and two unannounced inspections of the restaurant on Friday and Saturday, the health risk to the public was low.

You really do not think about typhoid here in the States.

And this reported in Reuters: Brazil's military will help fight an outbreak of dengue fever in Rio de Janeiro, the defense ministry said at the weekend, after the disease killed 49 people and made more than 30,000 ill this year.

Public hospitals in the northern and western districts of the city were overwhelmed by the number of patients seeking treatment at the weekend. Many complained about long delays.
The defense ministry said Army, Air Force and Navy commanders would propose an action plan to Defense Minister Nelson Jobim as early as Monday on how to combat the disease in the famous beach and port city.

And, watch out for canteloupes on the west coast USA.

sxsw: 3.11.08 Peas in a Pod: Advertising, Monetization and Social Media

sxsw: 3.11.08 Peas in a Pod: Advertising, Monetization and Social Media

Bottom line words: advertising ROI, social media

Tim Kendall is a Product Manager at Facebook, where he oversees revenue-generating products and leads new monetization initiatives including the company's new advertising solution, Facebook Social Ad system. Prior to Facebook, Tim worked in Amazon.com's digital media group as a Product Manager.

Ellen McGirt is Senior Writer at Fast Company magazine. She covers a range of business topics, but never stops looking for the writer's holy grail: The business ideas - and people - who are changing the world. McGirt joined Fast Company in February 2007 from Fortune, where she was a senior writer.

Kent Nichols is a storyteller, technology geek, and goofball. In 2003 his film "Baggage" won the International 48 Hour Film Project and Scott Billups called him the future of the entertainment industry in his book, "Digital Moviemaking." In 2005 Nichols, along with writing partner Douglas Sarine, created the Internet sensation AskANinja.com, which has been viewed over 20 million times. In 2006 Sarine and Nichols created HopeIsEmo.com, one of the most viewed and discussed series on the web.

Seth Goldstein is co-founder and chairman of Attentiontrust.org, and strongly advocates for the rights of individuals to their own data. He is creating services for turning passive data into active expression through a group called AttentionLab. I was the founder of one of the first Internet advertising agencies, SiteSpecific, in 1995, and was entrepreneur-in-residence at Flatiron Partners.

As the social web commands increasing user attention across diverse demographics, social media has begun to see a new wave of online advertising. As all kinds of marketers embark on this new media frontier, it's critical that their plans provide value for users while also creating demonstrating positive ROI - either for brand or direct marketers.

Companies push and have opt-in actions but some you have to opt out without really realizing this – so Beacon takes data outside Facebook, so if you buy something at Zappos it can come into Facebook.

Info shared within Facebook is fair game for sharing – it is a social sharing environment. When you move data from Facebook outward it needs more controls.

Social advertising network discussion is underway, but this conversation by this group is very stream of consciousness and not easy to blog.

Going to close my blogging now for this conference and see what I can learn from this one!